You must beware! Study links high insulin dose to cancer in type 1 diabetes patients

New York: Higher insulin dose is positively associated with cancer incidence, study finds.
The study, published in JAMA Oncology, looked at the correlation between daily insulin dose and cancer incidence (the number of new cases) in patients with type 1 diabetes, also found that the association was stronger in people with insulin resistance.
The results showed that traditional metabolic factors such as obesity (represented by body mass index), sugar control (represented by hemoglobin A1c) and blood pressure control are not associated with the cancer incidence in patients with type 1 diabetes.

“However, the incidence of cancer was higher in those who took high doses of insulin,” said Yuanjie Mao, assistant clinical professor at Ohio University in the United States.

Our findings imply that clinicians may need to balance potential cancer risk when treating patients with type 1 diabetes with a high daily insulin dose or that it may be best to improve sensitivity to insulin rather than just increasing the insulin dose,” he added.

To conduct the study, the team analyzed the associations of more than 50 common risk factors such as smoking, alcohol consumption, exercise, metabolic risk factors, medication use and history. family cancer incidence in 1,303 patients with type 1 diabetes whose data were collected over more than 28 years.

The study also found that age and sex are associated with cancer incidence when assessed separately and that a daily dose of insulin poses a higher cancer risk than age, especially a higher insulin dose.

Specifically, women were found to be at higher risk than men; however, it was unclear which risk factors may contribute to the higher incidence of cancer in type 1 diabetics.

Although previous studies have concluded that patients with diabetes have a higher risk of cancer in general, this is the first study to explore cancer incidence factors associated with type 1 diabetes.

“Type 1 diabetes accounts for about 5-10% of all diabetes cases, and recent studies of type 1 diabetes have also found a higher incidence of certain cancers such as stomach cancer, liver cancer , pancreas, endometrium and kidney in the population compared to the general population,” Mao explained.

“Whereas, in type 2 diabetes, an increased risk is attributed to metabolic factors such as obesity, chronic inflammatory state and insulin resistance.”

Disclaimer: This story was published by a news service and nothing except the title has been edited by Times Now.

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