Uses, Side Effects, Dosages, Interactions

What is Soolantra?

Soolantra is a prescription-only 1% topical cream used for the treatment of inflammatory rosacea lesions in adults. How Soolantra cream works (its mechanism of action) to treat rosacea lesions is unknown.

Medication Facts

Generic name: Ivermectin

brand names): Solantra

Availability of drugs: Order

Therapeutic classification: Pest control

Available generically: Yes

Controlled substance: N / A

Administrative route: Topical

active ingredient: Ivermectin

Dosage form(s): Cream

What is Soolantra used for?

Soolantra treats inflammatory rosacea lesions (red, inflamed areas of skin) in adults. It is estimated that approximately 415 million people suffer from rosacea worldwide. Rosacea is thought to be less commonly reported in people with colored skin due to gaps in knowledge and practice. Studies have shown that only about 18% of Americans with rosacea are currently treated.

How to take Soolantra

For Soolantra topical cream:

  • Wash your hands with soap and water before and after use.
  • Soolantra is for topical use only and should only be applied to your skin.
  • Use this medication as prescribed by your healthcare provider.
  • Use a pea-sized amount to apply a thin layer to the affected areas of your face (forehead, chin, nose, each cheek).
  • Do not get this medicine in the eyes, lips, nose or mouth.
  • If you accidentally apply Soolantra to a cut or scrape on your skin, wash the medicine off immediately.


Soolantra should be stored in a closed container at room temperature (about 68 to 77 degrees Fahrenheit), away from heat, moisture, and direct light. Do not freeze. It is permissible to take Soolantra on short excursions outside the home in temperatures between 59 and 86 degrees.

Keep your medications out of reach of children and pets, ideally locked in a cupboard or closet.

If you plan to travel with Soolantra, familiarize yourself with the regulations of your final destination. In general, be sure to make a copy of your Soolantra prescription. Try to keep your medicine in its original container from your pharmacy with your name on the label. If you have any questions about traveling with your medication, ask your pharmacist or healthcare professional.

Throw away all unused and expired medicine, but do not flush it down the drain or down the toilet. Ask your pharmacist or health care provider about the best ways to dispose of this medication. And check out the drug take-back programs in your area.

How long does Soolantra take to work?

According to the manufacturer, Soolantra takes about two weeks to start working.

Off-label uses

Topical ivermectin has been used for treatment-resistant scabies.

What are the side effects of Soolantra?

This is not a complete list of side effects and others may occur. A health care provider can advise you about side effects. If you experience any other effects, contact your pharmacist or healthcare provider. You can report side effects to the Food and Drug Administration (FDA) at or 800-FDA-1088.

Common side effects

For Soolantra Topical Cream:

  • Burning sensation
  • Skin irritation

Serious side effects

Call your healthcare provider right away if you notice any signs of an allergic reaction such as itching, hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness or breathing difficulties. If your symptoms are life-threatening or you think you have a medical emergency, please call 911.

Long term side effects

There are no known long-term side effects for these medications.

Report side effects

Soolantra can cause other side effects. Call your healthcare provider if you have any unusual problems while taking this medicine.

If you experience a serious side effect, you or your provider can send a report to the FDA MedWatch Adverse Event Reporting Program or by phone (800-332-1088).

Dosage: How much Soolantra should I take?

Contents of the drug supplied and reviewed by IBM Micromedex.

The dose of this drug will be different for different people. Follow your health care provider’s orders or label directions. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your healthcare provider tells you to.

The amount of medicine you take depends on the strength of the medicine. Also, the number of doses you take each day, the time between doses, and how long you take the medicine depends on the medical condition for which you are using the medicine.

The topical dosage form (cream) for rosacea:

  • Adults—Apply to affected area(s) of face once daily.
  • Children—Use and dose should be determined by your healthcare provider.


The following modifications (changes) should be kept in mind when using Soolantra:

Severe allergic reaction: Avoid using Soolantra if you have a known allergy to this product or any of its ingredients. Ask your pharmacist or health care provider for a complete list of ingredients if you are unsure.

Pregnancy: Not enough is known about the safety and effectiveness of Soolantra in pregnant women and their unborn fetuses. Talk to your health care provider if you are planning to become pregnant or if you are pregnant, and weigh the benefits and risks of using Soolantra during your pregnancy.

Breastfeeding: Soolantra may be present in breast milk. We don’t know enough about the safety of Soolantra in human breast milk and nursing babies. Talk to your health care provider if you plan to breastfeed, to weigh the benefits and risks of taking Soolantra while breastfeeding, and the different ways available to feed your baby.

Missed dose

If you accidentally forget your dose of Soolantra, apply it as soon as you remember. If it is already close to your next scheduled dose, skip the missed dose and apply the next dose at your next scheduled dosing time. Do not double the dose to make up for the missed dose.

Try to find ways that work to help you remember to take your medication regularly. If you miss too many doses, Soolantra might be less effective in treating your condition.

Overdose: what happens if I take too much Soolantra?

Because Soolantra is a topical medication, the possibility of an overdose is extremely rare. In case of accidental ingestion, supportive treatment may be used. Contact the poison control center if this product is accidentally ingested.

If you think you have an overdose or life-threatening symptoms, get medical help right away.

What happens if I overdose on Soolantra?

If you think you or anyone else may have overdosed Soolantra, call a healthcare provider or the Poison Control Center (800-222-1222).

If anyone collapses or is not breathing after taking Soolantra, call 911 immediately.


Contents of the drug supplied and reviewed by IBM Micromedex.

  • If your skin problem does not improve within a few days after using Soolantra or if it gets worse, talk to your healthcare professional.
  • Do not use this medication for any skin condition that has not been verified by your healthcare professional.
  • If you have any questions about this, check with your health care provider.

What are the reasons why I should not take Soolantra?

If you are allergic to Soolantra or any of its ingredients, avoid using it. Ask your pharmacist or health care provider for a complete list of ingredients if you are unsure.

What other drugs interact with Soolantra?

There are no specific drug interactions for topical ivermectin. For more detailed information about drug interactions with Soolantra, talk to your pharmacist or healthcare provider.

And be sure to talk with your healthcare provider about any other medications you take or plan to take, including over-the-counter (OTC, non-prescription) products, over-the-counter products, vitamins, herbs or herbal medicines.

Which drugs are similar?

The following drugs have been used to treat rosacea topically:

  • Avar (sulfacetamide/sulfur)
  • Benzoyl peroxide
  • Cleocin (clindamycin)
  • Differin (adapalene)
  • Eryc or Erythrocin (erythromycin)
  • Flagyl (metronidazole)
  • Mirvaso (brimonidine gel)
  • Nix (permethrin)
  • Retin-A or Avita (tretinoin)
  • Skinoren or Finacea (azelaic acid)
  • Silymarin (milk thistle) and methylsulfonylmethane (MSM, dimethylsulfone)

Frequently Asked Questions

  • What is Soolantra used for?

    To treat rosacea lesions.

  • How long does Soolantra take to work?

    According to the manufacturer, Soolantra takes about two weeks to start working.

  • Is Soolantra an over-the-counter drug?

    No. Soolantra requires a prescription for its use. You can’t find it on store shelves.

How can I stay healthy while taking Soolantra?

If you are using Soolantra to treat rosacea:

  • Do not use this medication for any skin condition that your healthcare professional has not reviewed and prescribed it for.
  • Be sure to call your health care provider if your symptoms do not improve or if they get worse.
  • Wear appropriate sunscreen and other sun protection.
  • Try to avoid your rosacea triggers.

Medical Disclaimer

Verywell Health medication information is for educational purposes only and is not intended to replace medical advice, diagnosis, or treatment from a healthcare provider. Consult your health care provider before taking any new medications. IBM Watson Micromedex provides some of the drug content as listed on the page.

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