Strength, shape, when to use, and more

If you have a certain type of cancer, your doctor might suggest Trodelvy as a treatment option.

Trodelvy is a prescription medicine used in adults to treat the following cancers in certain situations:

Trodelvy is a biological product, which means that it is made from living cells. The active ingredient in Trodelvy is sacituzumab govitecan-hziy. An active ingredient is what makes a drug work.

Trodelvy comes in powder form. A healthcare professional will mix it with a liquid to make a solution, which they will give to you as an intravenous (IV) infusion. (This is an injection into a vein given over time.) You will get the infusion at a clinic, doctor’s office, or hospital.

This article describes the dosages of Trodelvy, as well as its strength and how the drug is administered. To learn more about Trodelvy, check out this in-depth article.

To note: This article covers common Trodelvy dosages, which are provided by the drug’s manufacturer. But your doctor will prescribe the dose of Trodelvy that is right for you.

This section covers common prescribing information for Trodelvy. Before you begin treatment with Trodelvy, your doctor will discuss a dosage regimen specific to your condition.

What is the form of Trodelvy?

Trodelvy comes in powder form. A healthcare professional will prepare Trodelvy for administration by mixing the powder with liquid to make a solution. They will give you the medicine as an intravenous (IV) infusion (an injection into a vein given over time).

How strong is Trodelvy?

Trodelvy is available in one strength: 180 milligrams (mg).

What are the usual doses of Trodelvy?

Trodelvy dosage is based on body weight. Your doctor will calculate your dose using your weight in kilograms (kg).*

There is no loading dose for Trodelvy. (A loading dose is a higher dose of a medicine taken at the start of treatment. A higher dose may help the body react more quickly to certain medicines.) But if you have serious side effects from Trodelvy, your doctor may recommend a dose reduction. They will ultimately prescribe the smallest dose that provides the desired effect.

Your doctor may also prescribe medicines for you to take before each dose of Trodelvy to reduce the risk of certain side effects from Trodelvy.

The information below describes Trodelvy dosages that are commonly used or recommended. Your doctor will determine the best dosage to meet your needs.

* One kilogram equals approximately 2.2 pounds.

Dosage for urothelial cancer or breast cancer

The recommended dose for Trodelvy is 10 mg per kg body weight given on days 1 and 8 of a 21 day treatment cycle. Your doctor will ask you to repeat this cycle for as long as the medication is safe and effective for your condition.

Is Trodelvy used long term?

Yes, Trodelvy is generally used as a long-term treatment. If you and your doctor determine that Trodelvy is safe and effective for you, you are likely to use it long term.

If your cancer gets worse or you have serious side effects from this medicine, your doctor may ask you to stop treatment with Trodelvy.

Dosage adjustments

If you have certain side effects from Trodelvy, your doctor may lower your dose of Trodelvy. They can also slow down your infusion time.

Your doctor may ask you to permanently stop Trodelvy if your side effects are severe or if they persist after a dose reduction.

A healthcare professional will give you Trodelvy as an intravenous infusion in a clinic, doctor’s office or hospital. Before each dose, they may give you medicine to help prevent some side effects of Trodelvy.

You will receive your dose of Trodelvy on days 1 and 8 of a 21 day treatment cycle. In other words, you will receive a dose of Trodelvy on a day of the first and second weeks of a 3 week cycle. You will not receive a dose of Trodelvy during the third week of the cycle.

The infusion time for your first dose will probably be longer than for subsequent doses, as described below.

First infusion of Trodelvy

Your first infusion of Trodelvy will take approximately 3 hours. Afterwards, a healthcare professional will observe you for at least 30 minutes. They will watch for signs of serious side effects from the infusion or medication.

If you have serious side effects during the infusion, the healthcare professional may slow down or stop the infusion.

Infusions of Trodelvy after the premiere

If you do not have serious side effects on your first dose of Trodelvy, you will receive subsequent infusions over a period of 1 to 2 hours. As with your first dose, a healthcare professional will then monitor you for at least 30 minutes to see if you have any side effects.

The dosage of Trodelvy you are prescribed may depend on several factors. These include:

  • your weight
  • how the cancer you are using Trodelvy to treat responds to the medicine
  • side effects you may develop

It is important that you keep your appointments for your Trodelvy infusions. If you think you’re going to miss an appointment, contact your doctor’s office immediately to reschedule.

If you need help remembering your Trodelvy appointments, try marking your appointments on a calendar. You can also download a reminder app on your phone.

The sections above describe typical dosages provided by the drug manufacturer. If your doctor recommends Trodelvy, he will prescribe the dosage that is right for you.

Talk with your doctor if you have any questions or concerns about your current dosage.

Here are some sample questions you may want to ask your doctor:

  • Should I increase my dosage if Trodelvy is not working well enough for me?
  • Should I get a lower dose of Trodelvy if I have liver problems?
  • Would a slower infusion time reduce my risk of side effects from Trodelvy?

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Disclaimer: Healthline has made every effort to ensure that all information is factually correct, complete and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or for all specific uses.

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