Strength, shape, how to take, and more

If you have a certain type of lung cancer, your doctor might suggest Lumakras as a treatment option. It is a prescription medicine used to treat a type of non-small cell lung cancer (NSCLC) in adults.

It is specifically used to treat NSCLC:

  • that is locally advanced (spread to nearby lymph nodes or tissues outside the lungs) or metastatic (spread to other areas of the body)
  • who have the KRAS G12C genetic mutation (abnormal protein in lung cells that helps cancer cells grow)
  • in those who have received at least one type of systemic therapy (a type of therapy that travels through the bloodstream and affects the whole body)

Lumakras comes as a tablet that you swallow and contains the active ingredient sotorasib. (An active ingredient is what makes a medicine work.) It belongs to a group of medicines called RAS GTPase inhibitors.

This article describes Lumakras dosages, as well as its strength and how to take it. To learn more about Lumakras, check out this in-depth article.

To note: This article covers the usual dosages of Lumakras, which are provided by the manufacturer of the drug. But when taking this medicine, always follow the dosage prescribed by your doctor.

Below is some general information about Lumakras and its dosages.

What is the form of Lumakras?

Lumakras comes as a tablet that you swallow.

How strong is Lumakras?

Lumakras is available in a strength of 120 milligrams (mg).

What are the usual dosages of Lumakras?

The information below describes commonly used or recommended dosages. But be sure to take the dose your doctor has prescribed for you. They will determine the best dosage to meet your needs.

The typical dosage of Lumakras is 960 mg (eight tablets) taken once a day. It is best to take your daily dose at around the same time each day. Your doctor will discuss your dosage and monitor you for side effects while you take Lumakras. They will also check that the medicine is effectively treating your condition.

Is Lumakras taken long term?

Yes, Lumakras is generally used as a long-term treatment. If you and your doctor determine that it is safe and effective for you, you will likely take it long term.

Dosage adjustments

Some people may need dosage adjustments when taking Lumakras. Your doctor will describe the reasons why you may need a dose adjustment before starting treatment.

Dosage adjustments may be needed if you have certain serious side effects from taking Lumakras. These include:

If you experience any of the serious side effects listed above, your doctor will stop your treatment with Lumakras. Once you have recovered, they may restart you on a lower Lumakras dose of 480 mg (four tablets) once a day. Depending on how you treat your treatment at this dosage, you can continue at the lower dose.

But if you still experience serious side effects, your doctor may again interrupt your treatment until you recover. They can then restart Lumakras at the next lower dose of 240 mg (two tablets) taken once a day. They will monitor how you are doing with this dose. If the medication works and is safe, you will likely continue with this dosage. But if you still have serious side effects, they can permanently stop your Lumakras treatment.

The dosage of Lumakras you are prescribed may depend on several factors. These include:

  • other conditions you may have, such as other lung problems or liver problems (see ‘Dosage adjustments’ directly above)
  • serious side effects
  • other medications you are taking (the timing of your dosing schedule may need to be adjusted)

You will take Lumakras tablets by mouth. For the usual dose of 960 mg, you will swallow eight tablets with water. You can take Lumakras with or without food.

You should not crush, split or chew the tablets. If you have difficulty swallowing tablets, place the tablets in 120 milliliters (mL)* of room temperature water, stir and drink the entire contents. The tablets don’t dissolve completely, but you just have to swallow (not chew) what’s left. Then add another 120ml of water to rinse the inside of the glass and drink that too to make sure you get the full dose. (You can read the full manufacturer’s instructions for Lumakras here.)

You can also ask your doctor or pharmacist for more information and advice on how to swallow pills. Or check out this article.

For more information on Lumakra expiration, storage, and disposal, see this article.

*120 ml equals 4 ounces (oz)

Accessible medication containers and labels

If you have trouble reading the prescription label on your medications, talk to your doctor or pharmacist. Some pharmacies provide medication labels that:

  • have large print or use Braille
  • feature a code you can scan with a smartphone to change text to audio

Your doctor or pharmacist may be able to recommend pharmacies that offer these accessibility features if your current pharmacy does not.

If you have difficulty opening medicine bottles, tell your pharmacist. They may be able to supply Lumakras in an easy-open container. They may also have tips to make it easier to open the medicine container.

If you miss your regular daily dose of Lumakras, take it as soon as you remember. But if more than 6 hours have passed since your missed dose, skip it and continue with your next scheduled dose. If you vomit your usual dose of Lumakras, do not take that dose again.

And don’t take two doses of Lumakras at once to make up for a missed or vomited dose. It could cause serious side effects. If you are concerned about the missed dose, call your doctor’s office.

If you need help remembering to take your dose on time, try using a medication reminder. This may include setting an alarm or downloading a reminder app to your phone.

Do not take more Lumakras than your doctor has prescribed, as this can cause serious side effects.

What to do if you take too much Lumakras

Call your doctor right away if you think you have taken too much Lumakras. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use their online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

The sections above describe typical dosages provided by the drug manufacturer. If your doctor recommends Lumakras, he will prescribe the dosage that is right for you.

Remember that you should not change your dose of Lumakras without your doctor’s advice. Only take Lumakras exactly as prescribed. Talk with your doctor if you have any questions or concerns about your current dosage.

Here are some sample questions you may want to ask your doctor:

  • Will my dose change if I have serious side effects from Lumakras?
  • Will I need a different dose if I take certain other medicines with Lumakras?
  • Would a lower dose of Lumakras still work for my type of cancer?

Warning: Healthline has made every effort to ensure that all information is factually correct, complete and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or for all specific uses.

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