Side Effects, Dosage, Uses, Alternatives & More

Linzess can cause mild or severe side effects. They may vary depending on the condition the drug is being used to treat. The following lists contain some of the main side effects that can occur when taking Linzess. These lists do not include all possible side effects.

For more information about the possible side effects of Linzess, talk to your doctor or pharmacist. They can give you advice on how to deal with side effects that may be concerning or bothersome.

To note: The Food and Drug Administration (FDA) tracks the side effects of drugs it has approved. If you would like to notify the FDA of a side effect you have had with Linzess, you can do so via MedWatch.

Mild side effects

Mild side effects* of Linzess may include:

Most of these side effects may disappear within a few days to a few weeks. However, if they get worse or don’t go away, talk to your doctor or pharmacist.

*This is a partial list of mild Linzess side effects. For more information on other mild side effects, talk to your doctor or pharmacist, or check Linzess prescribing information.
† For more information on this side effect, see “Details of side effects” below.

Serious side effects

Serious Linzess side effects are not common, but they can occur. Call your doctor right away if you experience any serious side effects. Call 911 or your local emergency number if your symptoms are life-threatening or you think you have a medical emergency.

Serious side effects* of Linzess may include:

* For more information on this side effect, see ‘Details of side effects’ below.

Details of side effects

Here are some details about some side effects that this drug can cause. To find out how often side effects occurred in clinical trials, see the prescribing information for Linzess.

Headache

Although headaches were not a common side effect in people taking Linzess clinical testsit can still happen.

Headaches have only been reported in trials involving people who took Linzess for irritable bowel syndrome with constipation (IBS-C). People who took Linzess for chronic idiopathic constipation (CIC) did not report headaches.

A headache can cause a throbbing, sharp, or dull pain. You may feel pain on both sides of your head or just one.

what you can do

If you have frequent or bothersome headaches while taking Linzess, talk to your doctor. They may recommend an over-the-counter treatment option, such as acetaminophen (Tylenol), to ease your discomfort.

Diarrhea

Diarrhea may occur during treatment with Linzess. This was the most common side effect in people taking the drug in clinical tests. In most cases, the diarrhea was not serious. However, severe diarrhea has been reported.

Diarrhea occurred about as often whether people took Linzess for IBS-C or CIC.

Diarrhea was the most common reason people were prescribed a lower dose or stopped taking the drug.

Diarrhea usually starts to occur within the first 2 weeks of starting treatment with Linzess.

Symptoms of diarrhea can include bloating, abdominal pain, and loose, watery stools. With severe diarrhea, you tend to pass stools more forcefully and more often.

Severe diarrhea can sometimes lead to dehydration if you lose too much fluid. Symptoms of dehydration can include:

  • dry mouth or dry eyes
  • to be thirsty
  • headache
  • scared of heights

what you can do

If you have severe diarrhea while taking Linzess, tell your doctor. They can help determine if you should continue treatment with the medicine.

If you develop symptoms of dehydration, seek medical attention immediately.

To help prevent diarrhea and dehydration, your doctor will likely recommend that you stay hydrated and consume electrolytes. (These are chemicals that help keep your body hydrated.) Your doctor may recommend drinking water throughout the day or drinking rehydrating solutions such as Gatorade or Pedialyte.

Allergic reaction

As with most medicines, some people may have an allergic reaction after taking Linzess.

Symptoms of a mild allergic reaction may include:

A more serious allergic reaction is rare but possible. Symptoms of a severe allergic reaction may include:

  • swelling under the skin, usually in the eyelids, lips, hands, or feet
  • swelling of the tongue, mouth or throat
  • difficulty breathing

Call your doctor right away if you have an allergic reaction to Linzess, as the reaction could become serious. Call 911 or your local emergency number if your symptoms are life-threatening or you think you have a medical emergency.

Long term side effects

Linzess is not known to cause long term side effects.

Most side effects reported by people clinical tests only happened when they took Linzess. This means that side effects (such as diarrhea or bloating) may occur throughout treatment with Linzess. It is also possible that the side effects will improve as you continue to take the medicine. If your doctor asks you to stop treatment with Linzess, the side effects should go away.

If you have any questions about what to expect with Linzess, talk to your doctor.

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