Side effects, cost, dosage, uses, alternatives, etc.

The dosage of Jakafi prescribed by your doctor will depend on several factors. These include:

  • the type and severity of the condition you are taking Jakafi to treat
  • other medical conditions you may have, such as liver or kidney disease
  • other medicines you are taking
  • the platelet count in your blood
  • any side effects you may have

As a rule, your doctor will start your treatment with a low dose. Then they will adjust it over time to reach the amount that is right for you. Your doctor will ultimately prescribe the smallest dose that provides the desired effect.

The following information describes commonly used or recommended dosages. However, be sure to take the dose prescribed by your doctor. Your doctor will determine the best dosage to meet your needs.

Form and strengths of the drug

Jakafi comes in the form of an oral tablet in the following dosages:

  • 5 milligrams (mg)
  • 10mg
  • 15mg
  • 20mg
  • 25mg

Dosage for graft versus host disease (GVHD)

Jakafi is approved to treat both acute and chronic conditions graft versus host disease (GVHD). Below are the recommended dosages of Jakafi for these conditions.

Dosage for acute GVHD

The usual starting dose of Jakafi for acute GVHD is 5 mg twice daily. After 3 days, your doctor may increase your dose to 10 mg twice a day.

After 6 months of treatment, your doctor may decrease your dose of Jakafi every 8 weeks. This is whether the symptoms of GVHD come back or get worse. If your symptoms come back or get worse, they may ask you to continue treatment with your previous dose.

However, you should not start or stop treatment on your own. Be sure to follow your doctor’s dosage instructions.

Dosage for chronic GVHD

The usual dosage of Jakafi for chronic GVHD is 10 mg twice daily.

After 6 months of treatment, your doctor may decrease your dose of Jakafi every 8 weeks. This is whether the symptoms of GVHD come back or get worse. If your symptoms come back or get worse, they may ask you to continue treatment with your previous dose.

However, you should not start or stop treatment on your own. Be sure to follow your doctor’s dosage instructions.

Dosage for polycythemia vera

The usual starting dose of Jakafi for polycythemia vera is 10 mg twice a day. After 4 weeks, your doctor may increase your dose. It depends on how your body reacts to the drug. The maximum recommended dosage is 25 mg twice a day.

Dosage for Myelofibrosis

The starting dose of Jakafi for myelofibrosis is 5 mg to 20 mg twice a day. The maximum recommended dosage is 25 mg twice a day.

Your exact dosage of Jakafi will be based on the level of platelets in your blood. (Platelets are types of blood cells involved in blood clotting.) Your doctor will measure your platelet count before you start treatment with Jakafi. And they will continue to check your platelet count every 2-4 weeks until it is stable. This is because the drug can lower platelet levels as a side effect. (For more details, see the “Jakafi side effects” section above.)

Your doctor may adjust your dose of Jakafi each time they check your platelet count. They will do this until your platelets reach a stable level.

To learn more about Jakafi dosage for myelofibrosis, talk to your doctor. You can also consult the medicine prescribing information.

Dosage for children

Jakafi is approved to treat acute and chronic GVHD in children aged 12 years and older.

The dosage of Jakafi used in children is the same as that used in adults. For more details, see “Dosage for graft versus host disease (GVHD)” above.

What if I forget a dose?

If you miss a dose of Jakafi, skip the missed dose. You can take your next dose on your usual schedule.

Do not take an extra dose of Jakafi to make up for a missed dose. This could increase your risk of side effects with the drug. (For more information on possible side effects, see the “Jakafi side effects” section above.)

To make sure you don’t miss a dose, try using a medication reminder. This may include setting an alarm or using a timer. You can also download a reminder app on your phone.

How long can you take Jakafi?

Whether you take Jakafi long term depends on how your condition responds to treatment.

If you and your doctor determine that Jakafi is safe and effective for you, you will likely take it long term.

If your condition has not improved after 6 months of treatment, your doctor may recommend that you stop taking Jakafi.

Discuss with your doctor how long you will take Jakafi.

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