Side effects, cost, dosage, how to use, etc.

Like most medications, Nexletol can cause mild to severe side effects. The lists below describe some of the more common side effects it can cause. These lists do not include all possible side effects.

Keep in mind that the side effects of a medicine can depend on:

  • your age
  • other health problems you have
  • other medicines you are taking

Your doctor or pharmacist can tell you more about the potential side effects of Nexletol. They can also suggest ways to help manage side effects.

Mild side effects

Here is a list of some of the mild side effects that Nexletol can cause. For more information about other mild side effects, talk to your doctor or pharmacist, or read the Nexletol package leaflet. prescribing information.

Mild Nexletol side effects that have been reported include:

Mild side effects of many medications can disappear within days to weeks. But if they become bothersome, talk to your doctor or pharmacist.

*For more information on this side effect, see the “Side Effects Focus” section below.

Serious side effects

Serious Nexletol side effects may occur. If you have serious side effects from Nexletol, call your doctor right away. But if you think you have a medical emergency, you should call 911 or your local emergency number.

Serious Nexletol side effects that have been reported, which are described in the “Focus on Side Effects” section below, include:

Focus on side effects

Learn more about some of the side effects Nexletol can cause.

High level of uric acid

Nexletol can increase uric acid levels in your blood. This is called hyperuricemia.

Most people with hyperuricemia on Nexletol have no noticeable symptoms. But the following symptoms are possible:

  • severe foot pain, especially in the big toe
  • hot, red, or tender joints
  • swelling

Your blood uric acid level may increase within 4 weeks of starting Nexletol. They may continue to stay elevated while you are taking this medicine. Over time, high levels of uric acid can lead to gout (a type of arthritis).

Your doctor will monitor your uric acid level with blood tests during treatment.

What might help

To help prevent hyperuricemia while taking Nexletol, your doctor may recommend that you drink plenty of water. Be sure to tell your doctor if you or a family member has had high uric acid levels or gout.

Tell your doctor right away if you have symptoms of hyperuricemia. They can diagnose this condition with blood tests and a physical exam.

If your uric acid level is high or you have symptoms of hyperuricemia, your doctor may prescribe medication to lower the uric acid level in your blood. Examples include allopurinol (Zyloprim) and febuxostat (Uloric).

If you develop gout with Nexletol, your doctor may tell you to stop taking Nexletol. But you should not stop taking this drug without talking to your doctor first.

ruptured tendons

Nexletol can cause tendon damage, including tendon rupture. It refers to the tearing of a type of connective tissue that connects muscle to bone.

In studiesshoulder tears, bicep tears and tears in the Achilles’ tendon at the ankle were the most common. Symptoms of tendon problems can include swelling, inflammation, and pain in the area. Tendon rupture may occur within weeks or months of starting Nexletol.

Your risk of tendon rupture with Nexletol treatment is higher if you:

  • are aged 60 and over
  • taking other medicines that can also cause tendon rupture, such as corticosteroids or fluoroquinolones (a type of antibiotic)
  • have kidney failure
  • have had tendon problems in the past

What might help

If you have any of the following symptoms of tendon rupture, rest the area as much as possible and contact your doctor immediately:

  • hear or feel a pop in a tendon
  • bruising after injuring the area
  • inability to fully move or put weight on the body part

If you have a tendon rupture while taking Nexletol, your doctor will tell you to stop taking the medicine. They may also recommend stopping Nexletol if you have joint pain or swelling. But it is important that you do not stop taking Nexletol unless your doctor recommends it.

Be sure to tell your doctor if you have ever had a tendon rupture or have a tendon disorder. Your doctor probably won’t prescribe Nexletol for you in this case.

Tell your doctor about all the medications you are taking, in case any of them could also cause a tendon rupture. These include corticosteroids and a type of antibiotic called fluoroquinolones. Also tell your doctor if you have kidney failure, as this may increase your risk of tendon rupture.

Upper respiratory infection

Upper respiratory tract infection (sinus, nose or throat infection) was the most common side effect in studies of Nexletol. Although these infections are common with Nexletol, they are usually not serious.

Symptoms of an upper respiratory tract infection may include fever, stuffy nose, cough, or fatigue (low energy).

What might help

To prevent upper respiratory tract infections, it helps to:

  • wash your hands often with soap and water
  • avoid touching your face with unwashed hands
  • avoid contact with sick people

If your symptoms are severe, last longer than 7-10 days, or get worse after about a week, talk to your doctor. They can recommend treatment.

If you have a sinus, nose, or throat infection, you should stay home and not go to work or school. Coughing or sneezing into a tissue or your sleeve can help limit the spread of germs.

Allergic reaction

Some people may have an allergic reaction to Nexletol. Although no allergic reactions have been reported in studies of Nexletol, it can still happen.

Symptoms of a mild allergic reaction may include:

  • itchy skin
  • itching
  • rinsing (temporary warmth, redness or deepening of skin color)

A more serious allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include swelling under the skin, usually on the eyelids, lips, hands or feet. They can also include swelling of the tongue, mouth, or throat, which can lead to difficulty breathing.

Call your doctor right away if you have an allergic reaction to Nexletol. But if you think you have a medical emergency, call 911 or your local emergency number.

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