Pearl of daily medication: meropenem IV
Meropenem IV is an antibacterial drug indicated for the treatment of complicated infections of the stomach and skin structures.
Pearl of the day medication: Meropenem IV
Indication: Meropenem IV is an antibacterial drug indicated for the treatment of complicated bacterial infections of the stomach and skin structures in adult and pediatric patients 3 months of age and older; complicated intra-abdominal infections in adult and pediatric patients; and bacterial meningitis in patients 3 months of age and older.
- Dosage: 500 mg every 8 hours by intravenous infusion over 15 to 30 minutes in complicated skin and skin appendage infections (cSSSI) in adult patients. When treating infections caused by Pseudomonas aeruginosaa dose of 1 gram every 8 hours is recommended.
- Dosage forms: 500 mg vial of meropenem for injection (3) 1 gram vial of meropenem for injection.
- Adverse events: The most common side effects (2% or less) are headache, nausea, constipation, diarrhea, anemia, vomiting, and rash.
- Action mechanism: Meropenem penetrates the cell wall of most gram-positive and gram-negative bacteria to reach penicillin-binding protein (PBP) targets. Meropenem binds to PBPs 2, 3 and 4 of Escherichia coli and Pseudomonas aeruginosa; and PBP 1, 2 and 4 of Staphylococcus aureus. Bactericidal concentrations (defined as a 3 log10 reduction in cell count over 12 to 24 hours) are generally 1 to 2 times the bacteriostatic concentrations of meropenem, with the exception of Listeria monocytogenes, against which no lethal activity is not observed.