Pearl of daily medication: argatroban injection

Argatroban is indicated for thrombosis in adult patients with heparin-induced thrombocytopenia and as an anticoagulant in adult patients with or at risk of HIT undergoing percutaneous coronary intervention.

Pearl of the day medication: Argatroban Injection

Indication: Argatroban is a direct thrombin inhibitor indicated for the prophylaxis or treatment of thrombosis in adult patients with heparin-induced thrombocytopenia (HIT) and as an anticoagulant in adult patients with or at risk of HIT undergoing percutaneous coronary intervention.

Insight:

  • Dosage: Argatroban 125 mg in 125 mL of aqueous sodium chloride solution (1 mg/mL) is intended for administration to adult patients.
  • Dosage forms: Argatroban Injection is supplied as a single-use vial containing 125 mg of argatroban in 125 mL of aqueous sodium chloride solution.
  • Adverse events: In HIT patients, the most common adverse reactions (>5%) were dyspnoea, hypotension, fever, diarrhoea, sepsis and cardiac arrest.
  • Action mechanism: Argatroban is a direct thrombin inhibitor that binds reversibly to the active site of thrombin. Argatroban does not require the antithrombin III cofactor for antithrombotic activity. Argatroban exerts its anticoagulant effects by inhibiting reactions catalyzed or induced by thrombin, including the formation of fibrin; activation of coagulation factors V, VIII and XIII; activation of protein C; and platelet aggregation.

Source: Argatroban injection label (fda.gov)

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