Naltrexone HCl and Bupropion HCl (Contrave)

Contrave is indicated in addition to a calorie restricted diet and increased physical activity for chronic weight management in adults.

Pearl of the day medication: Naltrexone HCl and Bupropion HCl (Contrave)

Indication: Contrave is a combination of naltrexone, an opioid antagonist, and bupropion, an aminoketone antidepressant, indicated as an adjunct to a calorie restricted diet and increased physical activity for chronic weight management in adults with a body mass index baseline (BMI) of 30 kg/m2 or more (obese) or 27 kg/m2 or more (overweight) in the presence of at least 1 weight-related comorbidity (eg, hypertension, type 2 diabetes mellitus, or dyslipidemia ).

Insight:

  • Dosage: Take 1 tablet to start then 2 tablets over the weeks, according to the instructions.
  • Dosage forms: Sustained-release tablets 8 mg naltrexone hydrochloride/90 mg bupropion hydrochloride.
  • Adverse events: Most common side effects (greater than or equal to 5%): nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth and diarrhoea.
  • Action mechanism: Contrave has 2 components: naltrexone, an opioid antagonist, and bupropion, a relatively weak neuronal reuptake inhibitor of dopamine and norepinephrine. Non-clinical studies suggest that naltrexone and bupropion have effects on 2 distinct areas of the brain involved in the regulation of food intake: the hypothalamus (appetite regulation center) and the mesolimbic dopamine circuitry ( reward system). The exact neurochemical effects of Contrave leading to weight loss are not fully understood.

Reference: LABEL (fda.gov)

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