Janumet and Janumet XR Dosage: Form, Strengths, and More

Janumet and Janumet XR (sitagliptin/metformin) are brand name prescription drugs. They are approved by the Food and Drug Administration (FDA) to improve blood sugar levels in adults with type 2 diabetes. For this use, Janumet and Janumet XR are prescribed in conjunction with diet and exercise.

Janumet and Janumet XR come as oral tablets. Medicines differ in how they release their active ingredients into your body. Janumet contains the active medicines sitagliptin and an immediate-release (short-acting) form of metformin. Janumet XR contains the active ingredients sitagliptin and an extended-release (long-acting) form of metformin.

Sitagliptin belongs to a class of drugs called dipeptidyl peptidase-4 inhibitors, while metformin belongs to a class of drugs called biguanides.

Dosage Summary

The following table summarizes the dosage of Janumet and Janumet XR. Milligrams are abbreviated as mg. Your doctor will determine the dosage that is best for you.

* This is the recommended dosage for people already taking metformin 850 mg twice daily.
† This is the recommended dosage for people already taking metformin 850 mg or 1000 mg twice daily.

For more information on Janumet and Janumet XR dosage, including their strengths and how to take the medications, keep reading. For a complete overview of Janumet and Janumet XR, check out this article.

This article describes typical dosages for Janumet and Janumet XR provided by the drug manufacturer. When taking Janumet and Janumet XR, always follow the dosage prescribed by your doctor.

Below is important prescribing information for Janumet and Janumet XR.

Janumet and Janumet XR form

Janumet and Janumet XR come as oral tablets. Janumet comes as an immediate-release (IR) tablet and Janumet XR comes as an extended-release (ER) tablet.

Highlights of Janumet and Janumet XR

Janumet has two strengths:

  • 50 milligrams (mg) sitagliptin/500 mg metformin IR
  • 50 mg sitagliptin/1000 mg metformin IR

Janumet XR comes in three strengths:

  • 50 mg sitagliptin/500 mg metformin ER
  • 50 mg sitagliptin/1000 mg metformin ER
  • 100 mg sitagliptin/1000 mg metformin ER

Typical dosages

Generally, your starting dose will depend on whether or not you are already taking metformin. Metformin is a commonly prescribed medication for diabetes. It is one of the active drugs in Janumet and Janumet XR. Your doctor will adjust your dosage over time to reach the amount that is right for you. They will ultimately prescribe the smallest dose that provides the desired effect.

The following information describes commonly used or recommended dosages. However, be sure to take the dose prescribed by your doctor. Your doctor will determine the best dosage to meet your needs.

Janumet for type 2 diabetes

If you have never taken the medicine metformin, your typical starting dose of Janumet will be 50 mg sitagliptin/500 mg metformin. You will take one tablet twice a day.

If you are already taking metformin, your typical starting dose of Janumet will be 50 mg sitagliptin/1000 mg metformin. You will take one tablet twice a day.

The maximum daily dose of Janumet is 100 mg sitagliptin/2000 mg metformin.

Janumet XR for type 2 diabetes

If you have never taken the medicine metformin, your typical starting dose of Janumet XR will be 100mg sitagliptin/1000mg metformin. You will take one tablet once a day.

If you are already taking metformin, your typical starting dose of Janumet XR will be 100 mg sitagliptin/2000 mg metformin. You will take one tablet once a day. If you are taking metformin 850 mg twice daily or 1000 mg twice daily, you will usually take two Janumet XR 50 mg sitagliptin/1000 mg metformin ER tablets once daily.

The maximum daily dose of Janumet XR is 100 mg sitagliptin/2000 mg metformin.

Long term treatment

Janumet and Janumet XR are intended to be taken as long-term treatments. If you and your doctor determine that Janumet or Janumet XR is safe and effective for you, you are likely to take it long term.

If you miss a dose of Janumet or Janumet XR, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and take the scheduled dose. Do not double the doses to make up for the one you missed.

To make sure you don’t miss a dose, try using a medication reminder. This may include setting an alarm or using a timer. You can also download a reminder app on your phone.

You will take Janumet or Janumet XR as instructed by your doctor.

Janumet and Janumet XR come as tablets that you swallow.

The dosing instructions for Janumet and Janumet XR are as follows:

  • Take Janumet twice a day with meals.
  • Take Janumet XR once a day with a meal. If you are prescribed two tablets of Janumet XR, take them at the same time.

Do not crush, chew or divide Janumet or Janumet XR tablets. It is recommended to swallow the tablets whole. You should take Janumet or Janumet XR at around the same time each day. This helps maintain a constant level of medicine in your body so that Janumet or Janumet XR can work effectively.

If you have trouble swallowing tablets, see this article for advice on how to take this form of medication. You can also discuss this with your doctor or pharmacist.

Accessible medication labels and containers

If you have trouble reading your prescription label, talk to your doctor or pharmacist. Some pharmacies offer labels in large print, Braille, or with a code you scan with a smartphone to convert text to speech. If your local pharmacy does not offer these options, your doctor or pharmacist may be able to recommend a pharmacy that does.

If you have difficulty opening medicine bottles, ask your pharmacist to put Janumet and Janumet XR in an easy-open container. They can also recommend tools that can make opening bottles easier.

The dose of Janumet or Janumet XR prescribed by your doctor will depend on several factors. These include:

Other medical conditions you have may also affect your dosage of Janumet or Janumet XR.

If you take more Janumet or Janumet XR than your doctor prescribed, you may develop serious side effects.

It is important that you do not take more Janumet or Janumet XR than your doctor has advised.

Symptoms of an overdose

Symptoms of Janumet and Janumet XR overdose may include:

* Janumet and Janumet XR have a framed warning for this side effect. This is the most serious warning from the Food and Drug Administration (FDA).

If you take more than the recommended amount of Janumet and Janumet XR

Call your doctor right away if you think you have taken too much Janumet or Janumet XR. Another option is to call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

The dosages in this article are typical dosages provided by the drug manufacturer. If your doctor recommends Janumet or Janumet XR, they will prescribe the dosage that is right for you. Always follow the dosage prescribed by your doctor.

As with any medication, never change your dose of Janumet or Janumet XR without your doctor’s advice. If you have any questions about which dose of Janumet or Janumet XR is right for you, talk to your doctor.

Besides learning the dosage, you may want other information about Janumet or Janumet XR. These additional articles might be useful to you:

Warning: Medical News Today has made every effort to ensure that all information is factually correct, complete and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or for all specific uses.

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