Dosage, cost, side effects, uses, etc.

Before starting treatment with Xiaflex, it is important to discuss certain considerations with your doctor. This includes any medications you take or medical conditions you may have. This will help your doctor determine if Xiaflex is a safe and effective treatment option for you.

interactions

Taking medicine with certain vaccines, foods, and other things can affect how the medicine works. These effects are called interactions.

Before starting treatment with Xiaflex, be sure to tell your doctor about all medications you are taking, including prescription and over-the-counter medications. Also describe any vitamins, herbs or supplements you use. Your doctor or pharmacist can tell you about any interactions these may cause with Xiaflex.

For additional information on drug-condition interactions, see “Other Warnings” section below.

Interactions with Medications or Supplements

Xiaflex can interact with several types of medications. These medications include blood thinners (blood thinners) such as warfarin (Jantoven) and apixaban (Eliquis).

Your doctor or pharmacist can tell you more about these interactions and any other interactions that may occur with Xiaflex.

Framed warning

Xiaflex has a framed warning. This is a serious warning from the Food and Drug Administration (FDA) about the effects of drugs that can be dangerous.

In rare cases, treatment with Xiaflex for Peyronie’s disease can lead to penile fracture (breaking of certain tissues in the penis) and other serious damage to the penis. Symptoms can include:

What can help

If you are receiving Xiaflex to treat Peyronie’s disease and you experience any of the symptoms listed above, contact your doctor immediately.

To reduce the risk of injury to your penis, it is important not to engage in sexual activity for the majority of a Xiaflex treatment cycle. More specifically, you must:

  • Avoid sexual activity between the first and second injections of Xiaflex during a treatment cycle.
  • Avoid sexual activity after the second Xiaflex injection of a treatment cycle for at least 4 weeks. You should also wait until all pain and swelling in your penis is gone.

In addition, only certain doctors can prescribe Xiaflex through a Risk Assessment and Mitigation Strategy (REMS) Program. This is a drug safety program that the FDA requires for certain drugs. It is designed to ensure that these drugs are only used when their benefits outweigh their risks. To learn more about the Xiaflex REMS program, call 877-313-1235 or visit the program website.

Due to the risk of injury, doctors generally avoid prescribing Xiaflex to treat Peyronie’s disease if the plaque involves the urethra. (The urethra is a tube that carries urine out of the body.) In such cases, they will likely recommend other treatment options.

Other warnings

Xiaflex may not be right for you if you have certain medical conditions. These are known as drug-condition interactions. Other factors may also determine whether Xiaflex is a good treatment option for you.

Talk to your doctor about your medical history before receiving Xiaflex. Factors to consider include those listed below.

Blood clotting problem. People with blood clotting problems, such as haemophilia, have a higher risk of bleeding or bruising at Xiaflex injection sites. People who take blood thinners (blood thinners) also have a higher risk of this side effect.

If you have a blood clotting problem or are taking blood thinners, talk to your doctor before starting treatment with Xiaflex. This can help them determine if Xiaflex is safe for you or if another treatment option may be a better choice for you.

Allergic reaction. If you’ve had an allergic reaction to Xiaflex or any of its ingredients, your doctor probably won’t prescribe Xiaflex for you. Ask them what other medications are better options for you.

Xiaflex and alcohol

There is no known interaction between alcohol and Xiaflex.

If you have any questions about drinking alcohol with medications you are taking, talk to your doctor or pharmacist.

Pregnancy and breastfeeding

Xiaflex has not been studied in pregnancy, so it is not known if the medicine can be used safely in a pregnant person. It is also not known if it is safe to breastfeed while receiving the drug.

To learn more about your treatment options if you are pregnant or breastfeeding, or if you plan to become pregnant or breastfeeding, talk to your doctor.

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