Daily Medication Pearl: Pravastatin Sodium (Pravachol)

Pravastatin sodium (Pravachol) is indicated as an adjunct to diet to reduce the risk of myocardial infarction, revascularization, and cardiovascular mortality in hypercholesterolemic patients without clinically evident congenital heart disease.

Pearl of the day medication: Pravastatin sodium (Pravachol)

Indication: Pravastatin sodium (Pravachol) is an HMG-CoA reductase inhibitor (statin) indicated as an adjunct therapy to diet to reduce the risk of myocardial infarction, revascularization, and cardiovascular mortality in hypercholesterolemic patients without congenital heart disease clinically evident.

Insight:

  • Dosage: For adults, the recommended starting dose is 40 mg once daily. Use the 80 mg dose only for patients not reaching the LDL-C goal with 40 mg. In cases of significant renal impairment, the recommended starting dose is 10 mg once daily.
  • Dosage forms: Tablets 10 mg, 20 mg, 40 mg, 80 mg.
  • Adverse events: In short-term clinical trials, the most commonly reported adverse reactions (≥2% and >placebo) regardless of causality were musculoskeletal pain, nausea/vomiting, upper respiratory tract infection , diarrhea and headaches.
  • Action mechanism: Pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in the pathway. of cholesterol biosynthesis. Additionally, pravastatin reduces VLDL and TG and increases HDL-C.

Source: Pravachol Label (fda.gov)

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