D-Limonene for GERD: Effectiveness, Safety and Dosage

Gastroesophageal reflux disease (GERD) causes persistent and recurrent acid reflux. Doctors often prescribe antacids or proton pump inhibitors (PPIs) to manage symptoms, but some people prefer to use alternative approaches, such as d-limonene.

D-limonene is a compound that comes from the peel of citrus fruits. Some proponents of taking d-limonene for GERD argue that, unlike antacids and PPIs, d-limonene can reduce GERD symptoms without reducing stomach acid production, which is important for digestion and digestion. maintaining the health of the digestive tract.

However, there is little high quality studies proving it works in humans. So far, the main evidence supporting its use is anecdotal.

This article reviews d-limonene, whether it helps with GERD, its safety, and potential side effects.

D-Limonene is a chemical compound found naturally in the rind of citrus fruits, such as oranges or lemons. It belongs to a family of chemicals called terpenes. People can buy d-limonene as a dietary supplement. Companies also use it to give foods and drinks a citrus flavor.

Some scientists believe that d-limonene may have a range of beneficial health effects, such as:

Few studies have tested whether d-limonene reduces GERD symptoms in humans. Much of the existing research involves animals rather than human participants.

For example, a 2019 animal study demonstrated the protective effects of d-limonene on the gastrointestinal system in rats. The authors suggested that d-limonene produces its beneficial effect by increasing mucus production and regulating inflammatory and immune responses.

A study 2022 also mentions two human clinical trials in which participants with GERD “benefited significantly” from taking d-limonene. These tests took place under a US patent in 2002.

However, a study 2017 points out that at present there are few large, high-quality studies to prove that d-limonene is an effective approach. This means that more research is needed to confirm its use as a treatment for GERD.

The Food and Drug Administration (FDA) considers d-limonene “generally recognized as safe” (GRAS) when companies use it to add flavor to foods. This means that in moderate doses it is safe to ingest.

A older study reports that this substance has a low risk of toxicity, which means that a person would have to take a high dose to experience poisoning.

Some also argue that d-limonene might be useful for other conditions. For example, a 2021 study argues that as a relatively safe substance, d-limonene could potentially reduce inflammation in people with COVID-19.

However, the FDA has not approved d-limonene as a drug for GERD. This means that it has not undergone rigorous testing for safety or effectiveness. It also means that companies selling d-limonene as a supplement don’t need to prove its purity.

Additionally, people with citrus allergies may not be able to take d-limonene. There is not enough evidence to say whether d-limonene is safe for women who are pregnant, nursing, or have children.

People who want to try this approach should consult their doctor first. When buying d-limonene, always look for reputable brands where third-party labs have tested d-limonene to ensure its quality.

There is no standard or agreed-upon dose for d-limonene. The lack of human studies makes it difficult to say which dose will have the most effect.

However, d-limonene supplements tend to come in a range of dosages, including:

  • 250 milligrams (mg)
  • 500mg
  • 1000mg

If a doctor says it’s okay to take d-limonene, start with the lowest dose. If that doesn’t work, a person may want to try a higher dose.

Research suggests that d-limonene is safe for most people to take by mouth. However, there is a lack of data on potential side effects and their frequency, so some people may experience adverse reactions to this supplement.

Potential side effects include:

D-limonene can interact with certain medications. For example, it may affect the liver’s ability to break down other drugs. This could interfere with medical treatment and lead to a range of adverse effects.

Additionally, certain liver enzymes help the liver process limonene. Medications that increase the liver’s ability to do so may decrease the effects of a d-limonene supplement.

Although d-limonene seems safe, it’s always a good idea to speak with a doctor before trying any supplement. Here are some questions to ask:

  • Could d-limonene help with GERD?
  • Can I take it at the same time as my other medications?
  • Are there any good brands that you recommend?
  • How much should I take?
  • When and how often should I take d-limonene?

D-limonene is a naturally occurring chemical in citrus fruits. Animal studies and a limited number human trials suggest that this substance may have a protective effect on the gastrointestinal tract. Some report that it reduces GERD symptoms.

However, more research is needed to confirm whether d-limonene is a safe and effective treatment for GERD. Anyone considering taking d-limonene should consult their doctor first, especially if they are taking other supplements or medications or if they are pregnant.

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