ADHD Uses, Warnings, Side Effects, Dosage

Generic name: methamphetamine

Mark: Deoxyne

Drug class: CNS stimulants, Anorectics; Stimulants

What is methamphetamine and what is it used for?

Methamphetamine is a stimulant drug used to treat attention deficit hyperactivity disorder (ADHD) and obesity in adults and children over the age of six. Methamphetamine is a sympathomimetic amine that mimics the action of natural chemicals in the body that stimulate the sympathetic nervous system.

Methamphetamine increases the concentration of brain chemicals (neurotransmitters) dopamine, norepinephrine and serotonin, which stimulate the central nervous system. Methamphetamine promotes the release of these neurotransmitters and also blocks their reuptake (reuptake) after neurotransmission has been completed. Methamphetamine also inhibits monoamine oxidase, an enzyme that breaks down these neurotransmitters.

Dopamine, norepinephrine, and serotonin have multiple functions that include regulating digestion, the sleep-wake cycle, movement, attention, memory, motivation, and pleasure. Increased levels of these neurotransmitters improve concentration and reduce the hyperactive and impulsive behaviors associated with ADHD. Short-term clinical trials in obese patients show that methamphetamine suppresses appetite, but is unlikely to provide long-term benefit.

Stimulants, including methamphetamine, also increase heart rate, blood pressure and blood sugar, and dilate the airways. Stimulants have a high potential for abuse and addiction, and are used illegally as street drugs.

FDA-approved uses of methamphetamine include:

  • ADHD in patients over six years of age as part of a comprehensive treatment program including psychological, social and educational remedial measures.
  • Short-term treatment of obesity as an adjunct to calorie restriction in patients over 12 years of age whose obesity is refractory to other medications, diets, and group programs.

Methamphetamine is used off-label to treat narcolepsy, a chronic sleep disorder that causes daytime sleepiness.

What are the side effects of methamphetamine?

Common methamphetamine side effects include:

Rare and serious side effects of methamphetamine include:

Call your doctor right away if you experience any of the following symptoms or serious side effects while using this medication:

  • Serious heart symptoms include fast or pounding heartbeats, palpitations in the chest, shortness of breath, and sudden dizziness;
  • Severe headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady;
  • Severe nervous system reaction with very stiff muscles, high fever, sweating, confusion, fast or irregular heartbeat, shaking and feeling faint; Where
  • Serious eye symptoms include blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.

This is not a complete list of all side effects or adverse reactions that may occur while using this medication. Call your doctor for medical advice about serious side effects or adverse reactions. You can also report side effects or health concerns to the FDA at 1-800-FDA-1088.

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What are the dosages of methamphetamine?

Tablet: Annex II


Attention Deficit Hyperactivity Disorder

  • Initial: 5 mg orally daily or every 12 hours; may increase daily dose at weekly intervals by 5 mg/day until optimal response
  • Maintenance: the usual effective dose is 20 to 25 mg/day; the daily dose can be divided every 12 hours

Dosing Considerations

  • Whenever possible, drug administration should be interrupted occasionally to determine if there is a recurrence of behavioral symptoms sufficient to require continued therapy.

Obesity, short-term treatment

  • 5 mg PO every 8 hours, 30 minutes before each meal


Attention Deficit Hyperactivity Disorder

  • Children under 6 years old: safety and efficacy not established
  • Children 6 years and older: 5 mg orally daily or every 12 hours, possibly increasing daily dose at weekly intervals by 5 mg/day until optimal response (usually 20-25 mg/day)
  • The daily dose can be divided every 12 hours

Dosing Considerations

  • Whenever possible, drug administration should be interrupted occasionally to determine if there is a recurrence of behavioral symptoms sufficient to require continued therapy.


  • Children under 12: safety and efficacy not established
  • Children 12 and over: as adults; 5 mg PO every 8 hours 30 minutes before each meal


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  • Methamphetamine has a high potential for abuse and misuse resulting in tolerance, dependence, and withdrawal symptoms such as fatigue and mental depression upon discontinuation. Abuse and misuse of methamphetamine can lead to fatal cardiorespiratory arrest and death.
  • Symptoms of acute methamphetamine overdose include restlessness, tremors, overactive reflexes (hyperreflexia), rapid breathing, hallucinations, confusion, panic, fatigue, elevated body temperature (hyperpyrexia), cardiovascular symptoms such as as irregular heartbeat, changes in blood pressure and circulatory collapse, and gastrointestinal symptoms such as nausea, vomiting, diarrhea and abdominal cramps. Severe overdose can cause convulsions, coma and death.
  • Treatment of a methamphetamine overdose is based on symptomatic and supportive care. Undigested drug from the gastrointestinal tract can be removed by gastric lavage and administration of activated charcoal. The central nervous system (CNS) stimulating effects of methamphetamine can be reversed by administration of the sedative chlorpromazine.

What drugs interact with methamphetamine?

Tell your doctor about all the medications you are currently taking, he can advise you on possible drug interactions. Never start taking, suddenly stop or change the dosage of any medicine without your doctor’s advice.

  • Serious methamphetamine interactions include:
  • Methamphetamine has serious interactions with at least 36 different drugs.
  • Methamphetamine has moderate interactions with at least 204 different drugs.
  • Mild methamphetamine interactions include:

The drug interactions listed above are not all possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker.

It’s important to always tell your doctor, pharmacist, or health care provider about all prescription and over-the-counter medications you use, along with the dosage for each, and keep a list of the information. Check with your doctor or health care provider if you have any questions about the medicine.

Pregnancy and breastfeeding

  • There are no adequate and well-controlled studies of methamphetamine use in pregnant women, however, animal reproduction studies indicate that it may cause fetal harm. It can also cause premature labor, low birth weight, and withdrawal symptoms in newborns. Use methamphetamine during pregnancy only if the potential benefits to the pregnant woman outweigh the potential risks to the fetus.
  • Methamphetamine is excreted in breast milk. Mothers should not breastfeed while on methamphetamine treatment.

What else should I know about methamphetamine?

  • Methamphetamine is a Schedule II controlled substance, diversion of Schedule II products carries criminal penalties.
  • Take methamphetamine exactly as prescribed, do not take larger or more frequent doses.
  • Methamphetamine poses a high risk of addiction and dependence, and can lead to a fatal overdose, be careful.
  • Store methamphetamine safely out of reach of children.
  • In case of overdose, get medical help right away or contact the poison control center.
  • Methamphetamine can impair mental and physical abilities. Avoid driving, operating heavy machinery or other potentially dangerous tasks.

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Medical examination on 07/20/2022



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